Effects of polynucleotides and levamisole on alveolar macrophage morphology and receptor activity.
AUTOR(ES)
Daughada, C C
RESUMO
Incubation of rabbit pulmonary alveolar macrophages in vitro with polyinosinic acid-polycytidylic acid [poly(I-C)] or levamisole results in enhanced immunoglobulin G receptor activity in comparison to untreated cells, Electron microscopy of cells treated with levamisole or poly(I-C) revealed mitochondrial swelling and cytoplasmic vacuolization. The modulation of receptor activity by these agents suggests that their immunopotentiating effects are due to direct simulation of the mononuclear phagocyte system. Lavaged alveolar macrophages have the capacity to change membrane function in vitro, and these cells provide a convenient system for studying agents with potential effects on macrophages.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=421097Documentos Relacionados
- Alveolar macrophage-lymphocyte rosette formation: failure of levamisole to alter activity.
- Suramin effects on macrophage phagolysosome formation and antimicrobial activity.
- Tissue factor activity. A marker of alveolar macrophage maturation in rabbits. Effects of granulomatous pneumonitis.
- Monoclonal antibodies against beta nerve growth factor and their effects on receptor binding and biological activity.
- Comparison of live human neutrophil and alveolar macrophage elastolytic activity in vitro. Relative resistance of macrophage elastolytic activity to serum and alveolar proteinase inhibitors.