Effects of the physical activity on the vasculo-alveolar complex of the rats lung / Efeitos da atividade física aeróbia no complexo vásculo-alveolar no pulmão de ratos
AUTOR(ES)
Luciana Maria Bigaram Abrahão
DATA DE PUBLICAÇÃO
2009
RESUMO
The cardiovascular system is subject to important autonomic and haemodynamic adaptation by virtue of regular physical training. The aim of this study was to describe the effects of a treadmill physical training on the alveolar cytoarchitecture of the rats lung from a morphoquantitative and functional point of view. Additional aims were to quantify the heart rate (HR), arterial pressure (AP), lactate, arterial blood gases, glucose, triglycerides, total and fractional cholesterol. For this purpose fifteen 60-day-old male Wistar rats were used. Animals were divided into three groups: age control (CE, n=5), sedentary (SS, n=5) and trained rats (ST, n=5). After recording the haemodynamic parameters, the animals were euthanised and perfusion-fixed with a 4 % formaldehyde solution, which was also intratracheally instillated. Design-based stereological methods were applied for estimating the total number of alveolar openings as well as the lung volume using Cavalieris principle. The systolic arterial pressure (SAP) was 140.87 mmHg for the CE, 146.7 mmHg for the SS and 149.53 mmHg for the ST group (p=0.137). The diastolic arterial pressure (DAP) was 115.83 mmHg for the CE, 107 mmHg for the SS and 105.39 mmHg for the ST group (p=0.0004). The mean arterial pressure (MAP) was 128.93 mmHg for the CE, 125.22 mmHg for the SS and 125.34 mmHg for the ST group (p=0.332). HR was 388.4 bpm for the CE, 379.83 bmp for the SS and 370.85 bpm for the ST group (p=0.381). The lung volume was 1.05 cm³ for the CE, 1.24 cm³ for the SS and 0.95 cm³ for the ST group (p=0.484). The total number of alveolar openings alveolar was 21x106 for the CE, 25x106 for the SS and 38x106 for the ST group (p=0.02). The main findings of this research suggest that low-intensity treadmill physical training improves the haemodynamic parameters and increases the total number of alveolar openings of trained rats.
ASSUNTO(S)
lung ratos rats alvéolos pulmonares estereologia alveolar openings design-based stereology pulmão low-intensity physical training treinamento físico aeróbio crônico
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