Efficacy of Orally Delivered Cochleates Containing Amphotericin B in a Murine Model of Aspergillosis
AUTOR(ES)
Delmas, G.
FONTE
American Society for Microbiology
RESUMO
Cochleates containing amphotericin B (CAMB) were administered orally at doses ranging from 0 to 40 mg/kg of body weight/day for 14 days in a murine model of systemic aspergillosis. The administration of oral doses of CAMB (20 and 40 mg/kg/day) resulted in a survival rate of 70% and a reduction in colony counts of more than 2 logs in lungs, livers, and kidneys. Orally administered CAMB shows promise for the treatment of aspergillosis.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=127382Documentos Relacionados
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