Elastic model of supercoiling.

AUTOR(ES)

Benham, C J

RESUMO

An elastic model for the supercoiling of duplex DNA is developed. The simplest assumptions regarding the elastic properties of double-helical DNA (homogeneous, isotropic, of circular cross section, and remaining straight when unstressed) will generate two orders of superhelicity when stressed. Recent experimental results [Brady, G.W., Fein, D.B. & Brumberger, H. (1976) Nature 264, 231-234] suggest that in supercoiled DNA molecules there are regions where two distinct orders of supercoiling arise, as predicted by this model.

Documentos Relacionados

• Enhancer-activated plasmid transcription complexes contain constrained supercoiling.
• Regulation of the Escherichia coli nrd operon: role of DNA supercoiling.
• Gyrase inhibitors can increase gyrA expression and DNA supercoiling.
• Chromosomes in living Escherichia coli cells are segregated into domains of supercoiling.
• Regulation of the Escherichia coli DNA topoisomerase I gene by DNA supercoiling.