Elements of the polyomavirus replication origin required for homologous recombination mediated by large T antigen.
AUTOR(ES)
Laurent, S
RESUMO
We introduced various elements of the polyomavirus origin of DNA replication into the genome of rat cells, and we analyzed their capacity to elicit rearrangements within the integrated sequences when exposed to large T antigen. The cis-acting sequences required for homologous recombination were those that make up a functional replication origin.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=189659Documentos Relacionados
- High-frequency recombination mediated by polyomavirus large T antigen defective in replication.
- Optimal replication of plasmids carrying polyomavirus origin regions requires two high-affinity binding sites for large T antigen.
- Determination of the origin-specific DNA-binding domain of polyomavirus large T antigen.
- Amplification mediated by polyomavirus large T antigen defective in replication.
- Cyclin-dependent kinase regulation of the replication functions of polyomavirus large T antigen.