Enchancement of nitrosoguanidine mutagenesis by chloramphenicol in Escherichia coli K-12.

AUTOR(ES)

Sklar, R

RESUMO

N-methyl-N'-nitro-N-nitrosoguanidine-induced mutagenesis in E. coli K-12 can be enchanced up to 50-fold by the addition of chloramphenicol with minimal effect on survival. Chloramphenicol does not produce the expected proportionate increase in closely linked double mutations.

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