Endogenous carbohydrate-binding proteins in Pneumocystis carinii.

AUTOR(ES)

Vierbuchen, M

RESUMO

By using biotinylated neoglycoproteins, the in situ occurrence of endogenous carbohydrate-binding proteins (lectins) in Pneumocystis carinii has been glycohistochemically demonstrated in lung tissue specimens from acquired immunodeficiency syndrome patients with P. carinii pneumonia. While the parasite possessed only a weak to moderate density of receptors for L-fucose and N-acetylated amino sugars, a strong specific binding of beta-D-galactoside and D-mannoside neoglycoproteins was observed on the cyst surface and within intracystic bodies. It is suggested that these endogenous lectins may be involved in the adhesion of P. carinii to the target.

Documentos Relacionados

• Screening for carbohydrate-binding proteins in extracts of Uruguayan plants
• Developmentally Regulated, Carbohydrate-Binding Protein in Dictyostelium discoideum
• Identification of Carbohydrate-Binding Domains in the Attachment Proteins of Type 1 and Type 3 Reoviruses
• Endogenous lectins from cultured cells: nuclear localization of carbohydrate-binding protein 35 in proliferating 3T3 fibroblasts.
• Carbohydrate-binding sites of the mannose-specific fimbrial lectins of enterobacteria.