Enhanced In Vivo Immune Responses to Bacterial Lipopolysaccharide by Exogenous CD40 Stimulation
AUTOR(ES)
Barr, Tom A.
FONTE
American Society for Microbiology
RESUMO
The lack of specific T-cell help in immune responses to thymus-independent antigens results in weak, predominantly immunoglobulin M-mediated immunity with little or no memory. In the work presented here we show how the exogenous stimulation of CD40 by monoclonal antibodies can mimic T-cell help, resulting in enhanced immune responses which are protective against bacterial infection.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=116555Documentos Relacionados
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