Enhanced liposome-mediated activity of piperacillin against staphylococci.

AUTOR(ES)

Nacucchio, M C

RESUMO

This study showed that encapsulation of the beta-lactam antibiotic piperacillin (PIP) by liposomes prepared with phosphatidylcholine and cholesterol (1:1) protected the drug from hydrolysis by staphylococcal beta-lactamase. This was demonstrated by growth inhibition of Staphylococcus aureus in the presence of the liposomal preparation containing PIP at a 50% MIC. Growth inhibition was also seen when exogenous beta-lactamase was added. Furthermore, adsorption of PIP onto the surface of liposomes containing buffer conferred a significant degree of protection against enzymatic hydrolysis of the drug, thus enhancing its antistaphylococcal activity.

Documentos Relacionados

• Cationic liposome-mediated RNA transfection.
• Amphiphilic peptides enhance the efficiency of liposome-mediated DNA transfection.
• The role of helper lipids in cationic liposome-mediated gene transfer.
• Parameters Influencing the Liposome-Mediated Insertion of Fluorescein Diacetate into Plant Protoplasts
• Liposome-mediated transformation of tobacco mesophyll protoplasts by an Escherichia coli plasmid.