Enhancement of Antimicrobial Activity of Neuropeptide Y by N-Terminal Truncation
AUTOR(ES)
Shimizu, Mayumi
FONTE
American Society for Microbiology
RESUMO
The activity of neuropeptide Y (NPY) against Candida albicans, which was revealed to be fungicidal, was enhanced significantly by the truncation of amino acid residues at the N terminus. The most active peptides (MICs, approximately 1 μM) were about 10-fold more potent than the intact NPY (MIC, approximately 10 μM). The enhancement was weakened by the replacement of the N terminus by negatively charged residues and/or acylation of the α-amino group. These results suggest that only the α-helical region of NPY is necessary for the antimicrobial activity and that the net charge of the peptide is important for the activity.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=105930Documentos Relacionados
- Giardicidal activity of lactoferrin and N-terminal peptides.
- Enhancement of transforming potential of human insulinlike growth factor 1 receptor by N-terminal truncation and fusion to avian sarcoma virus UR2 gag sequence.
- An N-Terminal Truncation Uncouples the Sex-Transforming and Dosage Compensation Functions of Sex-lethal
- Control of protein life-span by N-terminal methionine excision
- Dynamic regulation of c-Jun N-terminal kinase activity in mouse brain by environmental stimuli