Enhancement of post-ultraviolet killing in Escherichia coli K-12 through the action of gyrase inhibitors: evidence for associated gyrase-recBC deoxyribonuclease function.
AUTOR(ES)
Purdy, M A
RESUMO
This work in conjunction with the results presented in an earlier report (M. A. Purdy and K. L. Yielding, Antimicrob. Agents Chemother. 10:182--184, 1976) showed the following. (i) Nalidixic acid and novobiocin could inhibit post-ultraviolet and post-X-ray survival, implicating gyrase function in deoxyribonucleic acid repair. (ii) The inhibition of post-ultraviolet survival requires the action of functional recBC deoxyribonuclease. (iii) Structural changes in the gyrase could (a) cause recBC mutants to exhibit enhancement of post-ultraviolet killing in the presence of novobiocin, (b) increase the ultraviolet sensitivity of recBC mutants, and (c) enhance the thermal lability of a recBCts mutant.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=352839Documentos Relacionados
- Nalidixic Acid Inhibition of Post-Ultraviolet Recovery in Escherichia coli K-12: Requirement for recBC Function
- Escherichia coli K-12 mutants in which viability is dependent on recA function.
- Ultraviolet-Sensitive Mutator Strain of Escherichia coli K-12
- Modification of Conjugation in ESCHERICHIA COLI K-12 by Ultraviolet Irradiation
- R Factors Improving Survival of Escherichia coli K-12 After Ultraviolet Irradiation
