Entry, dispersion and differentiation of microglia in the developing central nervous system
AUTOR(ES)
NAVASCUÉS, JULIO, CALVENTE, RUTH, MARÍN-TEVA, JOSÉ L., CUADROS, MIGUEL A.
FONTE
Anais da Academia Brasileira de Ciências
DATA DE PUBLICAÇÃO
2000-03
RESUMO
Microglial cells within the developing central nervous system (CNS) originate from mesodermic precursors of hematopoietic lineage that enter the nervous parenchyma from the meninges, ventricular space and/or blood stream. Once in the nervous parenchyma, microglial cells increase in number and disperse throughout the CNS; these cells finally differentiate to become fully ramified microglial cells. In this article we review present knowledge on these phases of microglial development and the factors that probably influence them.
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