Enzymes and Nucleotides in Virions of Rous Sarcoma Virus
AUTOR(ES)
Mizutani, Satoshi
RESUMO
In addition to the previously described deoxyribonucleic acid (DNA) polymerase, DNA ligase, DNA exonuclease, and DNA endonuclease activities, purified virions of Schmidt-Ruppin strain of Rous sarcoma virus (SRV) have nucleotides and nucleotide kinase, phosphatase, hexokinase, and lactate dehydrogenase activities. The SRV virions have no glucose-6-phosphate dehydrogenase activity. All enzyme activities, but glucose-6-phosphate dehydrogenase and adenosine triphosphatase, were increased by disruption of the virions. The DNA polymerase, DNA ligase, and hexokinase activities had a higher specific activity in purified virion cores. It is suggested that during assembly virions of SRV may pick up cytoplasmic components which bind to virion proteins. The role of these components in viral replication is not known at present.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=376214Documentos Relacionados
- Enzymes and Nucleotides in Virions of Rous Sarcoma Virus
- Comparison of Rous Sarcoma Virus-Specific Deoxyribonucleic Acid Polymerases in Virions of Rous Sarcoma Virus and in Rous Sarcoma Virus-Infected Chicken Cells
- Identification of a Packaged Cellular mRNA in Virions of Rous Sarcoma Virus
- Mass Determination of Rous Sarcoma Virus Virions by Scanning Transmission Electron Microscopy
- Cell-free synthesis of two proteins unique to RNA of transforming virions of Rous sarcoma virus.