Epinephrine-Induced Vacuole Formation in Parotid Gland Cells and Its Independence of the Secretory Process

AUTOR(ES)
RESUMO

Catecholamines cause rapid release of K+ and formation of vacuoles in acinar gland cells. A high K+ concentration in the medium bathing parotid gland slices prevents vacuole formation by epinephrine and facilitates the secretion of most of the exportable amylase. N6-monobutyryl 3′:5′-cyclic AMP does not cause K+ release and vacuole formation although it efficiently induces amylase secretion. It is suggested that the secretory process is independent of vacuole formation.

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