Epstein–Barr virus and Burkitt lymphoma
AUTOR(ES)
Brady, G
FONTE
BMJ Group
RESUMO
Burkitt lymphoma (BL) is an aggressive B‐cell malignancy with endemic, sporadic and immunodeficiency‐associated variants. It has been known for many years that the fundamental transforming event in BL is the translocation of the MYC gene, and the events that bring about this translocation and those that allow cells to survive with the constitutive expression of MYC have been the subject of intense investigation. Epstein–Barr virus (EBV) infection, malaria, immunodeficiency and spontaneous, somatic mutation can all contribute to the origin and maintenance of this cancer and their mechanisms are the subject of this review.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2095571Documentos Relacionados
- Epstein-Barr Virus Regulates c-MYC, Apoptosis, and Tumorigenicity in Burkitt Lymphoma
- Cellular and Epstein-Barr virus specific DNA polymerases in virus-producing Burkitt's lymphoma cell lines.
- Episomal and integrated copies of Epstein-Barr virus coexist in Burkitt lymphoma cell lines.
- DNA of Epstein-Barr Virus Detected in Tissue of Burkitt's Lymphoma and Nasopharyngeal Carcinoma
- Epstein-Barr Virus and the Somatic Hypermutation of Immunoglobulin Genes in Burkitt's Lymphoma Cells