Esquizofrenia: quarenta anos da hipótese dopaminérgica sob a ótica da Química Medicinal
AUTOR(ES)
Menegatti, Ricardo, Fraga, Carlos Alberto Manssour, Barreiro, Eliezer J., Lima, Vera Lucia Eifler, Rates, Stela Maris Kuze, Dalla Costa, Teresa
FONTE
Química Nova
DATA DE PUBLICAÇÃO
2004-06
RESUMO
Schizophrenia is a devastating psychiatric illness that affects 1-2% of the world population and continues as a challenge to neuroscience. In this work, we describe an account about the historical evolution of the dopaminergic hypothesis of schizophrenia discussing, from the medicinal chemistry point of view all different classes of antipsychotic drugs, emphasizing the rational design, structure activity relationships (SAR) and physico-chemical properties related with its molecular mechanism of action.
