Estado nutricional relativo à vitamina A e zinco e sua relação com estresse oxidativo em pacientes com Ataxia-Telangiectasia. / Estado nutricional relativo à vitamina A e zinco e sua relação com estresse oxidativo em pacientes com Ataxia-Telangiectasia. / Nutritional status concerning vitamin A and zinc their relation with oxidative stress in Ataxia-Telangiectasia Patients. / Nutritional status concerning vitamin A and zinc their relation with oxidative stress in Ataxia-Telangiectasia Patients.

AUTOR(ES)
FONTE

IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia

DATA DE PUBLICAÇÃO

22/02/2011

RESUMO

Ataxia-telangiectasia (A-T) is a rare and degenerative disease that leads to varying degrees of immunodeficiency, exacerbation of oxidative stress and malnutrition in over 50% of patients. Objectives: To evaluate the nutritional status, retinol and beta carotene plasmatic concentration and zinc serum and erythrocytes in patients with A-T. To correlate these concentrations with: malondialdehyde (MDA), T lymphocyte numbers (CD4+ e CD8+) and immunoglobulin (IgA). Methods: In a cross sectional study, prospective and controlled, we evaluated 14 patients with A-T and 14 healthy controls according to the Z score of BMI and height for age, body composition, dietary intake and laboratory tests. Results: The mean age of the groups was 13 years; 7 (50%) patients were malnourished. The patients exhibited lean body mass significantly lower compared to controls, p = 0.006. There was no difference between the concentrations of micronutrients or MDA between patients and controls. There was a negative correlation between MDA and the concentrations of retinol (r = - 0.628, p = 0.016) and a significant positive correlation between IgA levels and retinol (r = 0.633, p = 0.015). The average energy consumption and zinc was lower in patients compared to controls (p <0.05). Conclusion: The A-T patients showed a high percentage of malnutrition with a reduction of lean mass, however, changes in nutritional status concerning vitamin A and zinc wasnt observed.

ASSUNTO(S)

ataxia telangiectasia estresse oxidativo vitamina a zinco estado nutricional pediatria ataxia-telangiectasia, oxidative stress, vitamin a, zinc, nutritional status.

ACESSO AO ARTIGO

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