Estradiol decreases iodide uptake by rat thyroid follicular FRTL-5 cells
AUTOR(ES)
Furlanetto, Tania Weber
DATA DE PUBLICAÇÃO
2010
RESUMO
Estradiol has well-known indirect effects on the thyroid. A direct effect of estradiol on thyroid follicular cells, increasing cell growth and reducing the expression of the sodium-iodide symporter gene, has been recently reported. The aim of the present investigation was to study the effect of estradiol on iodide uptake by thyroid follicular cells, using FRTL-5 cells as a model. Estradiol decreased basal iodide uptake by FRTL-5 cells from control levels of 2.490 ± 0.370 to 2.085 ± 0.364 pmol I-/µg DNA at 1 ng/ml (P<0.02), to 1.970 ± 0.302 pmol I-/µg DNA at 10 ng/ml (P<0.003), and to 2.038 ± 0.389 pmol I-/µg DNA at 100 ng/ml (P<0.02). In addition, 4 ng/ml estradiol decreased iodide uptake induced by 0.02 mIU/ml thyrotropin from 8.678 ± 0.408 to 7.312 ± 0.506 pmol I-/µg DNA (P<0.02). A decrease in iodide uptake by thyroid cells caused by estradiol has not been described previously and may have a role in goiter pathogenesis.
ASSUNTO(S)
iodide uptake estradiol : uso terapeutico iodetos estradiol ratos thyroid follicular cells
ACESSO AO ARTIGO
http://hdl.handle.net/10183/21115Documentos Relacionados
- Estradiol decreases iodide uptake by rat thyroid follicular FRTL-5 cells
- Thyrotropin upregulates alpha 1-adrenergic receptors in rat FRTL-5 thyroid cells.
- Hormonal regulation of major histocompatibility complex class I genes in rat thyroid FRTL-5 cells: thyroid-stimulating hormone induces a cAMP-mediated decrease in class I expression.
- Complete nucleotide sequence of the cDNA for thyroid peroxidase in FRTL5 rat thyroid cells.
- Intrinsic bioactivity of thyrotropin in human serum is inversely correlated with thyroid hormone concentrations. Application of a new bioassay using the FRTL-5 rat thyroid cell strain.