Estratégias farmacológicas para a terapia anti-AIDS
AUTOR(ES)
Peçanha, Emerson Poley, Antunes, Octavio A. C., Tanuri, Amilcar
FONTE
Química Nova
DATA DE PUBLICAÇÃO
2002-12
RESUMO
The replicative cycle of HIV presents several events. The proteins involved in these events can be anticipated as pharmacological targets, aiming to the development of anti viral agents. Presently, there are fifteen commercially available anti-HIV drugs, which act at substrate binding site of reverse transcriptase (zidovudine, didanosine, zalcitabine, stavudine, lamivudine and abacavir), at a non-substrate binding site of reverse transcriptase (nevirapine, delavirdine and efavirenz), or by inhibiting HIV protease activity (saquinavir, ritonavir, indinavir, nelfinavir, amprenavir and lopinavir). The present review focus both on these established classes of drugs and on new classes of compounds acting on other virus specific steps.
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