Estudo da aterosclerose induzida por diferentestipos de dieta hiperlipídica em coelhos albinos(Oryctolagus cuniculus). / Study of atherosclerosis induced by diferente tipes of hiperlipidic diet in rabbits (Oryctolagus cuniculus)

AUTOR(ES)
DATA DE PUBLICAÇÃO

2008

RESUMO

The egg yolk chicken and pork lard as compared with other foods, have high cholesterol. 20 ml of gem shows on average 200 mg cholesterol and 20 ml of lard average value of 14 mg of cholesterol. Good food for experiences concerning cholesterol, are low cost compared them with cholesterol powder. Method: We used rabbits of New Zealand (n = 42) adults from 7 to 8 months of age divided into groups of 4: control group diet with 200 g and water ad libitum (G1), the group treated with 1 g of cholesterol (G2); group treated with 20 ml egg yolk (G3); group treated with 20 ml of lard (G4); group (G5) treated with 40 ml of yolk and the group (G6) treated with 40 ml of lard. All groups were fed during the period of 100 days with the aim of verifying which of the diet is best for induction of atherosclerosis. The blood collection for the dosages of the lipid profile of animals occurred at times 0, 30, 60 and 100 days. At the end of the trial period, the animals were subjected to euthanasia. Segments of the aortic arch, the right carotid artery and right femoral artery were collected for analysis histological. Results: As expected the group G1 not noticed amendment, the group G2 training light of atherosclerosis, the group returned G3 significant increase (p <0,05) in total cholesterol levels, the group G4 were not identified histological changes and G5 and G6 is not adapted the diet administered. By microscopic examination, were observed foam cells in the aortic arch, and femoral and carotid thickening of endothelium in the group G3 so significant comparing them with the G2. Conclusion: The diet enriched with egg yolk, chicken is the best option for formation of foam cells and thickening of endothelium, is practical and low cost for research on cholesterol and atherosclerosis.

ASSUNTO(S)

egg yolk colesterol foam cells células espumosas ciencias da saude pork lard aterosclerose banha de porco gema de ovo cholesterol atherosclerosis

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