Estudo da expressão dos genes regulatórios de hipóxia durante a inflamação pulmonar produzida pela isquemia e reperfusão intestinal em camundongos AIRmax e AIRmin / Study of hypoxia regulatory genes expression during lung inflammation produced by intestinal ischemia-reperfusion in AIRmax and AIRmin mice

AUTOR(ES)
DATA DE PUBLICAÇÃO

2009

RESUMO

Oxygen homeostasis is essential for survival and physiologic development of organisms. Lack of O2 in tissues is a common underlying factor in morbidity and mortality for numerous serious medical conditions such as the Acute Respiratory Distress Syndrome (ARDS). For homeostasis recovery the myeloid cells exert their functions in specialized areas of hypoxia. The adaptation of myeloid cells in low O2 tissue depends on the HIF-1α gene products. Hif-1α is a transcription factor that responds to O2 levels change. In this study we characterize, in two lines of mice selected for maximal (AIRmax) or minimal (AIRmin) Acute Inflammatory response (AIR), the cellular and molecular mechanisms operating in the hypoxia state during an acute inflammatory reaction in the lung parenchyma produced by mesenteric artery Ischemia. We observed an acute inflammatory reaction with high levels of Hif-1α and Vhl genes expression involved in hypoxia conditions and IL-1β and IL-6 genes showed related to high AIR in AIRmax mice.

ASSUNTO(S)

resposta inflamatória aguda fator indutor de hipóxia -1α hipoxia inducible factor -1α mice gene expresion acute respiratory distress syndrome ischemia camundongos expressão gênica síndrome do desconforto respiratório agudo isquemia acute inflammatory response

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