Estudo das alterações da resposta vasodilatadora e vasoconstritora em aortas de ratas diabéticas e os mecanismos envolvidos. / Study of the alterations of the vasodilator and the vasoconstrictor responses in aortas of the diabetic female rats and the mechanisms involved.

AUTOR(ES)

Simone Marcieli Sartoretto

DATA DE PUBLICAÇÃO

2009

RESUMO

Thirty days after induction of diabetes, in aortas with endothelium (E+) of diabetic female rats (DB), the maximum response (Rmax) to potassium chloride (KCl) was reduced and the Rmax to noradrenaline (NE) was similar to controls (CT). The endothelium (E-) removal increased the response to KCl and NE, but this increase was of a lower magnitude in DB than in CT. In aortas E+, the Rmax to NA: was not altered by superoxide anion scavenger or nitric oxide (NO) synthesis inhibition in DB, whereas in CT this response is reduced or increased, respectively, and was reduced only in DB after endothelin (ET) receptor blockade. The mobilization of the calcium (Ca2+) in response to NE was reduced in aortas E+ and E- of the DB. In aortas of DB, the alterations in the contractile apparatus, for example, reduction of the Ca2+ mobilization may be responsible for the reduction of the vasoconstriction. The reduction of NO modulation upon the response to NE or the increase of the ET release can be the responsible for the maintenance of the contractile response to NE.

ASSUNTO(S)

pharmacology fêmeas reatividade vascular aorta animal aorta de animal diabetes mellitus femeas vasos coronários coronary vessels vasos sanguìneos vascular reactivity farmacologia blood vessels diabetes mellitus

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