"Estudo de alguns parâmetros salivares em indivíduos com síndrome de DOWN" / Study measurement the flow rate concenntration whole saliva of individuals with Down syndrome.

AUTOR(ES)

Walter Luiz Siqueira Junior

DATA DE PUBLICAÇÃO

2005

RESUMO

The aim of this study was to measure the flow rate, pH, buffer capacity, sialic acid, total protein concentrations, amylase and peroxidase activities and sodium, potassium, calcium, phosphorus, zinc and magnesium concentration whole saliva of individuals with Down syndrome aged 1 - 25 years. In individuals aged 1-5 years the whole saliva was collected under slight suction, while in the others individuals aged 6-10, 11-15, 15-20, 21-25 the whole saliva was collected with stimulation by chewing a piece of parafilm, for 10 minutes. The pH and the buffer capacity were determined using a digital pHmeter. The buffer capacity was measured by titration with 0.01 N HCl. Electrolyte concentrations were determined by inductively coupled argon plasma with atomic emission spectrometry. Sialic acid was determined by thiobarbituric acid assay. Protein was determined by the folin’s phenol reagent. Amylase was assayed measuring the maltose produced by the breakdown of starch and peroxidase with ortho dianisidine. For statistical analysis the date are presented as mean ± SD. Student’s “t” test was used to determine differences between the mean of the Down syndrome and control groups. No statistically significant differences were observed in sialic acid, phosphorus, zinc, magnesium and calcium concentration between the individuals with Down syndrome and control group. The sodium and total protein concentration and buffer capacity showed higher in the Down syndrome than in the control group. On the other hand the flow rate and potassium concentration, amylase and peroxidase activities were lower in the Down syndrome than in the control group. These results suggest that the Down syndrome persons present alteration in the metabolism of the duct and/or acinar cells of salivary glands.

ASSUNTO(S)

ph sódio ph saliva salivary gland amilase magnesium total protein sialic acid potassium capacidade tampão flow rate amylase glândula salivar magnésio zinc saliva síndrome de down fluxo salivar cálcio buffer capacity zinco calcium peroxidase Ácido siálico fósforo sodium phosphorus potássio down syndrome peroxidase proteína total

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