ESTUDO EPIDEMIOLÃGICO E PERFIL DE RESISTÃNCIA ÃS DROGAS ANTI-TUBERCULOSE EM PACIENTES CO-INFECTADOS COM TB/HIV EM HOSPITAL DE REFERÃNCIA EM FORTALEZA-CEARÃ. / EPIDEMIOLOGICAL STUDY AND RESISTANCE PATTERNS TO THE ANTI-TUBERCULOSIS DRUGS IN MYCOBACTERIA AND HIV CO-INFECTED PATIENTS IN A REFERENCE HOSPITAL IN FORTALEZA, CEARÃ.
AUTOR(ES)
BrÃulio Matias de Carvalho
FONTE
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia
DATA DE PUBLICAÇÃO
31/08/2007
RESUMO
The HIV infection and the tuberculosis (TB) are together the main causes of death for infectious agents in the world, being approximately 13 million people infected with both causative agents. The HIV-infected individuals show increased susceptibility for active tuberculosis, being the imunosupression caused by the virus the main risk factor for the development for active TB. This study investigated the profile of Mycobacterium tuberculosis drug resistance and evaluated the factors related to the development of TB in HIV infected patients who were treated at HSJ, which is a reference hospital in infectious diseases in Fortaleza, CearÃ, Brazil. During the period of July 2003 until June 2006, 208 patients with clinical and/or laboratorial diagnosis of micobacteriosis or tuberculosis and infection for the HIV were taken care in this hospital. The TB/HIV co-infected patients were older (average: 40 years, p= 0.0025) than the control group, being approximately 4 years older. The majority of the patients were male (80.8%, p= 0.0005) and they had shown a risk to develop TB of 43.0% greater compared to the female sex. The risk to develop the TB disease was two times higher in the patients with lower educational levels (less than eight years of schooling) and they represented 85.9% of the patients (p=0.000). The history of previous contact with TB patients and previous treatment for TB were also found to be risk factors for TB. The imunosupression level was higher in TB-HIV coinfected patients being the CD4+ lymphocytes count average of 169 cells/mm Â(p=0.000) and the viral load logarithm average of 4,36 (p=0.0013). The clinical forms most frequents were pulmonary (45.7%), extrapulmonary (28.4%) and disseminated (25.9%). Of the samples that were submitted to identification, 81.2% were M. tuberculosis and 12.8% were not M. tuberculosis. The resistance frequency to one drug and multi-resistance were the same (5.9%). Overall, these observations are important for establishing political strategies of public health to improve the conditions at the regional level.
ASSUNTO(S)
doencas infecciosas e parasitarias hiv mycobacterium tuberculosis tuberculose fatores de risco sÃndrome de imunodeficiÃncia adquirida hiv mycobacterium tuberculosis tuberculosis risk factors acquired immunodeficiency syndrome
ACESSO AO ARTIGO
http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=2504Documentos Relacionados
- Abandono do tratamento de tuberculose em co-infectados TB/HIV
- A dimensão epidemiológica da coinfecção TB/HIV
- Sociodemographic and health profile of TB/HIV co-infection in Brazil: a systematic review
- Clinical and epidemiological characteristics associated with unfavorable tuberculosis treatment outcomes in TB-HIV co-infected patients in Brazil: a hierarchical polytomous analysis
- Eleven million adults co-infected with AIDS, TB