Estudo fitoquímico de Auxemma glazioviana Taub.

AUTOR(ES)

Costa, J. Galberto M., Magalhães, Hemerson I. F., Lemos, Telma L. G., Pessoa, Otília D. L., Pinheiro, Gilvandete M.

FONTE

Revista Brasileira de Farmacognosia

DATA DE PUBLICAÇÃO

2002

RESUMO

Phytochemical investigation of heartwood of Auxemma glazioviana (Boraginaceae) has led to the isolation of three benzoquinones, one hydroquinone identified as: oncocalyxone A (1), oncocalyxone C (2), glazioviana A (3), glaziovianol (4) besides allantoin (5) α-bisabolol (6) and α-cadinol (7). Their structures were determined based on spectral analysis, including 2D NMR experiments. Essential oil obtained from heartwood by hydrodistillation was analyzed by GC/MS. The major constituents were identified as α-bisabolol and α-cadinol. The oil was active against larvae of dengue (Aedes aegypti ) with DL50 2.98 ppm.

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