Estudo fitoquimico de Lecointea hatschbachii Barneby

AUTOR(ES)
DATA DE PUBLICAÇÃO

2004

RESUMO

A PHYTOCHEMiCAL STUDY ABOUT Lecointea hatschbachii BARNEBY had the purpose to isolare and elucidate the present flavonoid structures in the roots extracts of the plant Lecointea hatschbachii Barneby. The genus Lecointea has six reported species, alI of them chemically unexplored, and it is localized inside the Lecointea group, Swartzia tribe, Papilionoideae subfamily, of Leguminosae, the Swartzia tribe encompasses species. Some recent studies propose that the Lecointea group is not monophyletic, which inspired our research group in order to verify chemotaxonomic correlations which could support the taxonomic review suggested by Tozzi, A.M. G. A. The analysis of the chloroformic extract from Lecointea hatschbachii Barneby roots resulted in the isolation of tive isoflavonoids, (being three of them unreported), namely: 7, 2,4-trihydroxy-6 (a,a-dimethylallyl)-3-methoxyisoflavone,3 - hydroxy-9,10-chromenecoumestan, e 3,9-dihydroxy-7(a,a.-dimethylallyl)-10-methoxy- coumestan, besides the aIready known isosojagol e medicarpin, were isolated. The compounds identification was performed by of H and C RMN, COSY of , H, HMBC, HSQC, NOE, UV and IR spectroscopy and high resolution mass spectrometry. The fact that the isolated substances are isoflavonoids with a similar oxidation pattern, besides the oxidation/methylation ratio typical of the Swartzia tribe species, evidenciated that Lecointea hatschbachii is well placed inside the same tribe. After the Artemia salina lethality test, it was evident hexane extract activity, medicarpin activity and two inedited coumestans activity, and by bioauthography, it was evident the new isoflavone activity, against Penicillium fimiculosum, medicarpin activity, against Aspergillus niger and new trihydroxy coumestan activity, against Staphylococcus aureus and Alternaria alternata.

ASSUNTO(S)

flavonoides cumestano lecointea

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