Evaluation of a common receptor-complement concept for predicting the antileukemic activity of nucleosides.

AUTOR(ES)

Townsend, L B

RESUMO

The triangulation arrangement of one nitrogen and two oxygen atoms proposed as a requirement for antileukemic activity involving a "common receptor-complement feature" has been reevaluated specifically as it applies to nucleosides. This re-evaluation has resulted in a rejection of the "receptor-complement feature" as a working model for the a priori design of nucleosides as compounds active against leukemia L-1210.

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