Evaluation of Acute Hematologic and Long-Term Pulmonary Toxicities of Radioimmunotherapy of Cryptococcus neoformans Infection in Murine Models

AUTOR(ES)

Dadachova, E.

FONTE

American Society for Microbiology

RESUMO

We evaluated acute hematological and long-term pulmonary toxicity of radioimmunotherapy in murine models of Cryptococcus neoformans infection. Activities up to 250 μCi were well tolerated by healthy A/JCr mice for 213Bi-18B7 and 188Re-18B7 monoclonal antibodies. In infected mice, doses up to 150 μCi produced only transient toxicity. The lungs of treated mice had no evidence of radiation fibrosis.

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