Evaluation of cellular immune response during chronic schistosomiasis in humans by the leukocyte aggregation test and the leukocyte migration inhibition test.
AUTOR(ES)
Rouveix, B
RESUMO
Cellular immune response was evaluated in 31 patients with chronic Schistosoma haematobium and Schistosoma mansoni infections and in 15 healthy normal persons by using S. mansoni soluble worm and egg antigens. Although the leukocyte migration inhibition test demonstrated false-positive reactions, the specificity of the leukocyte aggregation test was confirmed by the negativity of all of the controls. Among the patients, only 10% were positive for the leukocyte aggregation test. This low cellular reactivity was in contrast to markedly elevated specific humoral response determined by an enzyme-linked immunosorbent assay for immunoglobulin G and paper allergosorbent test for immunoglobulin E with soluble worm antigen. These results confirm that the cellular immune reactivity to schistosome antigen as demonstrated by the leukocyte aggregation test is either minimal or absent in chronically infected patients.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=271742Documentos Relacionados
- Cell response in rabbits infected with T. pallidum as measured by the leucocyte migration inhibition test.
- Cellular immune response during uncomplicated genital infection with Chlamydia trachomatis in humans.
- Inhibition of Leukocyte Migration by a Staphylococcal Factor
- Leukocyte Migration Inhibition in Chorioretinitis
- Monocyte migration explains the changes in macrophage arachidonate metabolism during the immune response.
