Evaluation of Haemophilus influenzaetype b carrier status among children 10 years after the introduction of Hib vaccine in Brazil
AUTOR(ES)
Zanella, Rosemeire Cobo, Brandileone, Maria Cristina de Cunto, Andrade, Ana Lúcia, Ogassavara, Cinthya Terumi, Fiório, Cleiton Eduardo, Brandão, Angela Pires, Almeida, Samanta Cristine Grassi, Lemos, Ana Paula Silva, Gorla, Maria Cecília, Carvalhanas, Telma Regina, Sato, Helena, Liphaus, Bernadete, Nerger, Maria Lígia, Conde, Monica, Ribeiro, Ana Freitas
FONTE
Mem. Inst. Oswaldo Cruz
DATA DE PUBLICAÇÃO
2015-09
RESUMO
The aim of the present study was to assess the prevalence of Haemophilus influenzaetype b (Hib) nasopharyngeal (NP) colonisation among healthy children where Hib vaccination using a 3p+0 dosing schedule has been routinely administered for 10 years with sustained coverage (> 90%). NP swabs were collected from 2,558 children who had received the Hib vaccine, of whom 1,379 were 12-< 24 months (m) old and 1,179 were 48-< 60 m old. Hi strains were identified by molecular methods. Hi carriage prevalence was 45.1% (1,153/2,558) and the prevalence in the 12-< 24 m and 48-< 60 m age groups were 37.5% (517/1,379) and 53.9% (636/1,179), respectively. Hib was identified in 0.6% (16/2,558) of all children in the study, being 0.8% (11/1,379) and 0.4% (5/1,179) among the 12-< 24 m and 48-< 60 m age groups, respectively. The nonencapsulate Hi colonisation was 43% (n = 1,099) and was significantly more frequent at 48-< 60 m of age (51.6%, n = 608) compared with that at 12-< 24 m of age (35.6%, n = 491). The overall resistance rates to ampicillin and chloramphenicol were 16.5% and 3.7%, respectively; the co-resistance was detected in 2.6%. Our findings showed that the Hib carrier rate in healthy children under five years was very low after 10 years of the introduction of the Hib vaccine.
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