Evaluation of pulmonary function in amyotrophic lateral sclerosis holders through forced vital capacityin the seated and supine position / Avaliação da função pulmonar em pacientes portadores de esclerose lateral amiotrofica por meio da capacidade vital forçada, na posição sentada e supina

AUTOR(ES)

Wander de Oliveira Villalba

DATA DE PUBLICAÇÃO

2001

RESUMO

Amyotrophic lateral sclerosis ( ALS ) is a progressive fatal neurodegenerative disorder of unknown origin, characterized by degeneration of espinal motor neurons, motor nuclei of the lower brain stem and upper neurons of the motor cortex. Eventually these lesions may produce respiratory failure. The aim of this study was to assess the variations of the measurements of forced vital capacity and maximum voluntary ventilation in patients with Amyotrophic Lateral Sclerosis when the subjects moved from the sitting to supine position and also to determine the maximum inspiratory and expiratory pressures, in order to evaluate repiratory muscle strength. 21 ALS patients participated of the study ? 11 females and 10 males, whose ages ranged from 20 to 74 years. Only patients with an ALS diagnosis confirmed, who undergone a careful clinical evaluation complemented by an electromyographic exam and a nerve conduction study, that texcluded all other neuromuscular diseases, were included. All the patients undergone physiotherapeutic assessment and the Manuvacumeter Recorder (IMEBRAS) with a capacity for 150 cc of water was used to measure the maximum inspiratory (MIP) and expiratory pressures (MEP). Spirometry was performed with the ANAMED AM 4000 PC spirometer. All the patients were measured for the Forced Vital Capacity (FVC), the Forced Expiratory Volume during the first second (FEV 1) and Maximum Voluntary Ventilation (M V V) in sitting and supine position, comparatively. The Wilcoxon non-parametric test was used to check if there was a statistical difference between the variables measured in the sitting position minus 25%, 20% and 15% and the same values measured in the supine position. Values of p ?

ASSUNTO(S)

esclerose amiotrofica lateral espirometria neurologia doenças neuromusculares

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