Evidence for a cellular gene with potential oncogenic activity in plants.
AUTOR(ES)
Hansen, C E
RESUMO
During tumor inception in crown gall disease, a portion of the tumor-inducing (Ti) plasmid, the transferred DNA (T-DNA), is integrated into the genome of the plant cell. Autonomous growth of the transformants requires expression of genes in the tmr and tms regions of the T-DNA, which code for enzymes concerned with biosynthesis of the plant growth hormones cytokinin and auxin, respectively. We show that a mutation of the Habituated leaf gene, Hl, of tobacco can compensate for a defective tmr locus in expression of the tumor phenotype. This provides evidence that a specific host-cell gene has an oncogenic function similar to tmr in the T-DNA.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=323324Documentos Relacionados
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