Evidence for Balancing Selection at Hla
AUTOR(ES)
Hedrick, Philip W.
RESUMO
HLA data from the A and B loci for 22 populations were compared with the neutrality expectations from Ewens' sampling theory. In 25 of 44 cases, there was significantly less homozygosity than expected. Although a number of factors can affect homozygosity in this manner, upon close examination only symmetrical balancing selection appears to be consistent with these data.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1202087Documentos Relacionados
- New evidence for balancing selection at the HLA-G locus in South Amerindians
- Strong balancing selection at HLA loci: Evidence from segregation in South Amerindian families
- Evidence for balancing selection operating at the het-c heterokaryon incompatibility locus in a group of filamentous fungi
- Evidence for Balancing Selection from Nucleotide Sequence Analyses of Human G6PD
- Polymorphism and Balancing Selection at Major Histocompatibility Complex Loci
