Evidence for Mitotic Recombination in W(ei)/+ Heterozygous Mice
AUTOR(ES)
Panthier, J. J.
RESUMO
A number of alleles at coat color loci of the house mouse give rise to areas of wild-type pigmentation on the coats of otherwise mutant animals. Such unstable alleles include both recessive and dominant mutations. Among the latter are several alleles at the W locus. In this report, phenotypic reversions of the W(ei) allele at the W locus were studied Mice heterozygous in repulsion for both W(ei) and buff (bf) [i.e. W(ei)+/+bf] were examined for the occurrence of phenotypic reversion events. Buff (bf) is a recessive mutation, which lies 21 cM from W on the telomeric side of chromosome 5 and is responsible for the khaki colored coat of nonagouti buff homozygotes (a/a; bf/bf). Two kinds of fully pigmented reversion spots were recovered on the coats of a/a; W(ei)+/+bf mice: either solid black or khaki colored. Furthermore phenotypic reversions of W(ei)/+ were enhanced significantly following X-irradiation of 9.25-day-old W(ei)/+ embryos (P < 0.04). These observations are consistent with the suggestion of a role for mitotic recombination in the origin of these phenotypic reversions. In addition these results rise the intriguing possibility that some W mutations may enhance mitotic recombination in the house mouse.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1204000Documentos Relacionados
- Mitotic recombination produces the majority of recessive fibroblast variants in heterozygous mice
- Phenotypic reversions at the W/Kit locus mediated by mitotic recombination in mice.
- Evidence for Mitotic Recombination in the Cellular Slime Mold Dictyostelium discoideum
- H-2 hemizygous mutants from a heterozygous cell line: role of mitotic recombination.
- Long-Tract Mitotic Gene Conversion in Yeast: Evidence for a Triparental Contribution during Spontaneous Recombination