Evidence for oligoclonal B cell expansion in the peripheral blood of patients with rheumatoid arthritis.
AUTOR(ES)
Fox, D A
RESUMO
Peripheral blood lymphocytes from patients with rheumatoid arthritis and osteoarthritis were examined for evidence of oligoclonal B cell expansion using the computer assisted flow cytometric technique of kappa-lambda (kappa-lambda) analysis. Eleven of 29 patients with rheumatoid arthritis but only one of 16 with osteoarthritis gave abnormal results (p less than 0.025). Abnormal kappa-lambda determinations did not correlate with age, duration of disease, presence of rheumatoid factor, or other clinical and laboratory parameters. Therapy with oral or intramuscular gold compounds appeared to diminish the incidence of kappa-lambda abnormality. These findings may indicate defective control of clonal B cell proliferation in rheumatoid arthritis.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1002038Documentos Relacionados
- Evidence of antigen receptor-influenced oligoclonal B lymphocyte expansion in the synovium of a patient with longstanding rheumatoid arthritis.
- Morphological evidence that activated polymorphs circulate in the peripheral blood of patients with rheumatoid arthritis.
- Characterisation of activated lymphocytes in the peripheral blood of patients with rheumatoid arthritis.
- Reduction of peripheral blood lymphocytes in patients receiving gold therapy for rheumatoid arthritis.
- Natural killer (NK) cell activity of peripheral blood, synovial fluid, and synovial tissue lymphocytes from patients with rheumatoid arthritis and juvenile rheumatoid arthritis.