Evidence for two distinct retinoic acid response pathways for HOXB1 gene regulation.
AUTOR(ES)
Ogura, T
RESUMO
We have recently identified a promoter proximal retinoic acid (RA)-responsive site in the 5' region of the HOXB1 gene. In this report, we have identified the second RA-responsive site in the 3' region of the HOXB1 gene. This site also consists of a DR-2-type target of RA receptor.retinoid X receptor complex (DR-2B) and the binding site for a distinct RA-dependent coactivator termed retinoid-activating protein, which shows a different tissue-specific spectrum from the 5' responsive site. This indicates that the activation of the HOXB1 gene is achieved through two distinct pathways. These data define an unusual regulatory mechanism leading to the establishment of HOXB1 gene expression.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=42746Documentos Relacionados
- A retinoic acid-triggered cascade of HOXB1 gene activation.
- A retinoic acid-responsive element in the apolipoprotein AI gene distinguishes between two different retinoic acid response pathways.
- Retinoic acid response element in the human alcohol dehydrogenase gene ADH3: implications for regulation of retinoic acid synthesis.
- Two genetically distinct pathways for transcriptional regulation of anaerobic gene expression in Salmonella typhimurium.
- "Estudo de mutações nos genes HOXA1 e HOXB1 em pacientes com síndrome de Moebius"