Evidence of muscarinic acetylcholine receptors in the retinal centrifugal system of the chick
AUTOR(ES)
Calaza, K.C., Gardino, P.F.
FONTE
Brazilian Journal of Medical and Biological Research
DATA DE PUBLICAÇÃO
2000-09
RESUMO
In this study we characterize the presence of muscarinic acetylcholine receptors (mAChR) in the isthmo-optic nucleus (ION) of chicks by immunohistochemistry with the M35 antibody. Some M35-immunoreactive fibers were observed emerging from the retinal optic nerve insertion, suggesting that they could be centrifugal fibers. Indeed, intraocular injections of cholera toxin B (CTb), a retrograde tracer, and double-labeling with M35 and CTb in the ION confirmed this hypothesis. The presence of M35-immunoreactive cells and the possible mAChR expression in ION and ectopic neuron cells in the chick brain strongly suggest the existence of such a cholinergic system in this nucleus and that acetylcholine release from amacrine cells may mediate interactions between retinal cells and ION terminals.
Documentos Relacionados
- Influence of melatonin on the development of functional nicotinic acetylcholine receptors in cultured chick retinal cells
- Muscarinic acetylcholine receptors of the developing retina.
- Frequent occurrence of nicotinic acetylcholine receptors in GABAergic neurons of the chick visual system
- Activation of muscarinic acetylcholine receptors elicits pigment granule dispersion in retinal pigment epithelium isolated from bluegill
- Properties of muscarinic acetylcholine receptors in heart cell cultures