Evolution of the Helicobacter pylori Vacuolating Cytotoxin in a Human Stomach
AUTOR(ES)
Aviles-Jimenez, Francisco
FONTE
American Society for Microbiology
RESUMO
We describe two subclones of Helicobacter pylori, isolated contemporaneously from a human stomach, which differ markedly in the vacuolating cytotoxin gene, vacA, but whose near identity in sequences outside this locus implies a very recent common origin. The differences are consistent with homologous recombination with DNA from another strain and result in a changed vacA midregion and, importantly, in changed toxicity.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=451639Documentos Relacionados
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