Evolution of the major histocompatibility complex: molecular cloning of major histocompatibility complex class I from the amphibian Xenopus.
AUTOR(ES)
Flajnik, M F
RESUMO
Class I major histocompatibility complex (MHC) cDNA clones have been isolated from an expression library derived from mRNA of an MHC homozygous Xenopus laevis. The nucleotide and predicted amino acid sequences show definite similarity to MHC class I molecules of higher vertebrates. The immunoglobulin-like alpha-3 domain is more similar to the immunoglobulin-like domains of mammalian class II beta chains than to those of mammalian class I molecules, and a tree based on nucleotide sequences of representative MHC genes is presented.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=50846Documentos Relacionados
- Evolution of the major histocompatibility complex: isolation of class II A cDNA clones from the cartilaginous fish.
- Evolution of the opossum major histocompatibility complex: evidence for diverse alternative splice patterns and low polymorphism among class I genes
- Evolution of immunoglobulin genes: VH families in the amphibian Xenopus.
- Concerted evolution of class I genes in the major histocompatibility complex of murine rodents.
- Transmembrane domain length variation in the evolution of major histocompatibility complex class I genes.