Experimental periodontal disease treatment by subgingival irrigation with tetracycline hydrochloride in rats
AUTOR(ES)
Fernandes, Leandro Araújo, Martins, Thiago Marchi, Almeida, Juliano Milanezi De, Nagata, Maria José Hitomi, Theodoro, Leticia Helena, Garcia, Valdir Gouveia, Bosco, Alvaro Francisco
FONTE
Journal of Applied Oral Science
DATA DE PUBLICAÇÃO
2010-12
RESUMO
OBJECTIVE: The aim of this study was to compare subgingival irrigation with tetracycline hydrochloride (TTC-HCL) as adjunctive treatment to scaling and root planning (SRP) on induced periodontitis in rats. MATERIAL AND METHODS: In 60 rats, periodontal disease was ligature-induced at the mandibular left first molar. After 7 days, the ligature was removed and all animals were submitted to SRP, and divided into 2 groups according to the following treatment: C (n=30) - subgingival irrigation with 1 mL of saline; T (n=30) - subgingival irrigation with 1 mL of TTC-HCL (50 mg/mL). Ten animals in each group were euthanized at 7, 15 and 30 days posttreatment. The histometric values were statistically analyzed (p<0.05). RESULTS: In the histometric analysis, at 7, 15 and 30 days, Group T (0.72±0.05 mm², 0.57±0.14 mm², 0.62±0.07 mm²), showed less bone loss (p<0.05) than Group C (1.35±0.25 mm²; 1.40±0.31 mm²; 1.29±0.27 mm²), respectively. CONCLUSIONS: Subgingival irrigation with TTC-HCL was an effective adjunctive treatment for periodontal disease induced in rats.
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