Experimental Production of Lethal Escherichia coli Bacteremia of Pelvic Origin
AUTOR(ES)
Braude, A. I.
RESUMO
To reproduce the syndrome of overwhelming Escherichia coli bacteremia and shock after pelvic instrumentation, a model was developed by feeding E. coli via drinking water to coliform-free rabbits, injecting nitrogen mustard intravenously, and inserting a temperature probe into the rectum. The temperature probe was inserted to mimic pelvic instrumentation of patients and to detect fever. Rabbits fed invasive serotypes of E. coli all suffered overwhelming bacteremia with high fever and fatal vascular collapse secondary to invasion of pelvic veins as the granulocyte count approached zero. In the absence of granulocytopenia, the rectal temperature probe produced an intensive inflammation with numerous polymorphonuclears and bacteremia did not develop. In the absence of rectal probing, granulocytopenic rabbits developed high fever without bacteremia. This model resembles human bacteremic shock with respect to the endogenous source of the bacteria, the high frequency of bacteremia due to E. coli and other enteric bacilli, the importance of pelvic instrumentation, and the associated immune disturbances such as granulocytopenia.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=315284Documentos Relacionados
- Efficacy of cefmenoxime in experimental Escherichia coli bacteremia and meningitis.
- Recurrent Escherichia coli bacteremia.
- Effect of neonatal gastrointestinal colonization with cross reacting Escherichia coli on anticapsular antibody production and bacteremia in experimental Haemophilus influenzae type b disease of rats.
- Leukemia inhibitory factor protects against experimental lethal Escherichia coli septic shock in mice.
- Efficacy of BMY-28142 in experimental bacteremia and meningitis caused by Escherichia coli and group B streptococci.