Experimental ulcerative herpetic keratitis. III. Evaluation of hyperimmune gammaglobulin therapy.
AUTOR(ES)
Carter, C A
RESUMO
The value of hyperimmune gammaglobulin (HGG) therapy in ulcerative herpetic keratitis was assessed in rabbits. HGG treated of early disease in normal rabbits was very effective, producing a 10-fold rise in the virus concentration needed to infect 50% of sites (CID50) and an 88% inhibition of ulceration after 2 days. The efficacy of the gammaglobulin preparations tested depended on their anti-HSV antibody content. Established disease was considerably less responsive to HGG therapy. No conclusive effect of HGG therapy could be demonstrated in rabbits with a previous HSV skin infection ('immunised'). Corticosteroid-induced geographic ulceration in immunised rabbits was not prevented by concurrent HGG therapy. The findings indicate that HGG is unlikely to represent a useful therapy for ulcerative herpetic keratitis but that it may be valuable in primary disease and in long-term prophylaxis.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1039531Documentos Relacionados
- Sequential antibody changes following ulcerative herpetic keratitis.
- Experimental ulcerative herpetic keratitis. II. Influence of topical corticosteroid in immunised rabbits.
- Experimental ulcerative herpetic keratitis. I. Systemic immune responses and resistance to corneal infection.
- Experimental ulcerative herpetic keratitis. IV. Preliminary observations on the efficacy of a herpes simplex subunit vaccine.
- A comparison of acyclovir and idoxuridine as treatment for ulcerative herpetic keratitis.
