Experiments with cloned complete tumor-derived bovine leukemia virus information prove that the virus is totally exogenous to its target animal species.
AUTOR(ES)
Deschamps, J
RESUMO
Taking advantage of the existence of a unique SacI restriction site in the long terminal repeats of the integrated bovine leukemia virus proviral DNA isolated from a bovine tumor, the total viral information (about 9.2 kilobases) was cloned in the lambdoid vector lambda WES. lambda B. Use of this cloned bovine leukemia virus DNA allowed us, for the first time, to definitely rule out the existence of any endogenous bovine leukemia virus sequence in the bovine, ovine, caprine, murine, feline, chicken, or human genomes. These data prove the absence of acquired cellular information in the provirus that has given rise to a tumor.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=256666Documentos Relacionados
- Keratins as markers that distinguish normal and tumor-derived mammary epithelial cells.
- Secreted frizzled-related protein 4 is a potent tumor-derived phosphaturic agent
- p73 Function Is Inhibited by Tumor-Derived p53 Mutants in Mammalian Cells
- In Vivo Rescue of a Silent tax-Deficient Bovine Leukemia Virus from a Tumor-Derived Ovine B-Cell Line by Recombination with a Retrovirally Transduced Wild-Type tax Gene
- Isolation and primary structure of tumor-derived peptides related to human pancreastatin and chromogranin A.
