Expression of raf oncogenes activates the PEA1 transcription factor motif.

AUTOR(ES)

Wasylyk, C

RESUMO

PEA1 (AP1) motif transcription enhancer activity was stimulated by v-raf and more efficiently by activated c-raf-1 or A-raf than by their normal counterparts, in agreement with a role for PEA1 in transformation by raf. Mutations in the ATP-binding site of v-raf prevented activation, suggesting that phosphorylation is somehow required.

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