Expression of Variant Surface Antigens by Plasmodium falciparum Parasites in the Peripheral Blood of Clinically Immune Pregnant Women Indicates Ongoing Placental Infection
AUTOR(ES)
Ofori, Michael F.
FONTE
American Society for Microbiology
RESUMO
Placenta-sequestered Plasmodium falciparum parasites that cause pregnancy-associated malaria (PAM) in otherwise clinically immune women express distinct variant surface antigens (VSAPAM) not expressed by parasites in nonpregnant individuals. We report here that parasites from the peripheral blood of clinically immune pregnant women also express VSAPAM, making them a convenient source of VSAPAM expressors for PAM vaccine research.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=148875Documentos Relacionados
- Phenotypes of Plasmodium falciparum from the Peripheral Blood of Pregnant Women
- Analysis of IgG with specificity for variant surface antigens expressed by placental Plasmodium falciparum isolates
- Prevalence of Plasmodium falciparum infection in pregnant women in Gabon
- Detection of the Plasmodium falciparum Antigen Histidine-Rich Protein 2 in Blood of Pregnant Women: Implications for Diagnosing Placental Malaria
- Plasmodium falciparum Infection Elicits Both Variant-Specific and Cross-Reactive Antibodies against Variant Surface Antigens