Extensive homology between the leukotoxin of Pasteurella haemolytica A1 and the alpha-hemolysin of Escherichia coli.
AUTOR(ES)
Strathdee, C A
RESUMO
The 19.8- and 101.9-kilodalton leukotoxin proteins of Pasteurella haemolytica (LKTC and LKTA, respectively) share extensive homology with the HLYC and HLYA alpha-hemolysin proteins of Escherichia coli. The leukotoxin LKTA protein cross-reacts with hemolysin-specific antisera in Western blot (immunoblot) analysis, indicating that it shares epitopes with the alpha-hemolysin HLYA protein. Both LKTA and HLYA contain a conserved hydrophobic region, as well as a set of tandemly repeated domains. These features have been implicated in the lytic function of the alpha-hemolysin.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=260059Documentos Relacionados
- Composition of affinity-purified alpha-hemolysin of Escherichia coli.
- Characterization of monoclonal antibodies against alpha-hemolysin of Escherichia coli.
- Association between alpha-hemolysin production and HeLa cell-detaching activity in fecal isolates of Escherichia coli.
- Immune response to Escherichia coli alpha-hemolysin in patients.
- Cloning and expression of the leukotoxin gene of Pasteurella haemolytica A1 in Escherichia coli K-12.
