Extinction of alpha-fetoprotein gene expression in somatic cell hybrids involves cis-acting DNA elements.
AUTOR(ES)
Widen, S G
RESUMO
alpha-Fetoprotein (AFP), a liver-specific protein, is extinguished in somatic cell hybrids formed by the fusion of mouse hepatoma cells (BWTG3) with rat fibroblast cells (JF1). Our studies show that the extinction of mouse AFP expression in these somatic cell hybrids may involve at least two cis-acting regulatory domains, i.e., the enhancer elements and a tissue-specific promoter region, which are located in the 5'-flanking region of the AFP gene.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=365398Documentos Relacionados
- Liver-specific expression of the mouse alpha-fetoprotein gene is mediated by cis-acting DNA elements.
- Derepression of a mouse alpha-fetoprotein expression vector in COS-1 cells by amplification of specific cis-acting sequences of the AFP promoter.
- PLACE: a database of plant cis-acting regulatory DNA elements.
- Human erythropoietin gene expression in transgenic mice: multiple transcription initiation sites and cis-acting regulatory elements.
- Different cis-acting DNA elements control expression of the human apolipoprotein AI gene in different cell types.
