Extracellular localization of pokeweed antiviral protein.
AUTOR(ES)
Ready, M P
RESUMO
Pokeweed antiviral protein is an enzyme of Mr 29,000 known to inactivate a wide variety of eukaryotic ribosomes. We have used electron microscopy to show that the antibody specific for the protein is bound within the cell wall matrix of leaf mesophyll cells from Phytolacca americana. Any penetration or breakage of the cell wall and membrane could allow the enzyme to enter the cytoplasm, where it is likely to inhibit protein synthesis in the damaged cell. We speculate that pokeweed antiviral protein is a defensive agent whose principal function is probably antiviral.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=323888Documentos Relacionados
- Poliovirus-mediated entry of pokeweed antiviral protein.
- Inhibition of herpes simplex virus DNA synthesis by pokeweed antiviral protein.
- Inhibition of herpes simplex virus multiplication by the pokeweed antiviral protein.
- Broad-spectrum virus resistance in transgenic plants expressing pokeweed antiviral protein.
- Anti-human immunodeficiency virus type 1 activity of an anti-CD4 immunoconjugate containing pokeweed antiviral protein.
