Extracellular superoxide dismutase in human tissues and human cell lines.
AUTOR(ES)
Marklund, S L
RESUMO
Extracellular-superoxide dismutase is a tetrameric copper-containing glycoprotein that previously has been demonstrated to be the major superoxide dismutase of human extracellular fluids. The occurrence of this enzyme in various human tissues that were removed from two accidental death victims and in 19 different human cultured cell lines was determined. All investigated tissues were found to contain extracellular-superoxide dismutase. There was a larger variation between tissues in the concentration of this enzyme than in CuZn superoxide dismutase and Mn superoxide dismutase. No relation could be demonstrated between the content of extracellular-superoxide dismutase and the content of the other superoxide dismutase isoenzymes in the various tissues. In uterus there was more extracellular-superoxide dismutase than Mn superoxide dismutase, but in all other tissues the content of extracellular-superoxide dismutase was lower than the content of the other isoenzymes. The concentration of extracellular-superoxide dismutase was higher in all investigated human tissues than in human plasma. 19 human cultured cell lines were found to be devoid of or to contain very little extracellular-superoxide dismutase. Most tissues contained more extracellular-superoxide dismutase than did the investigated cell lines.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=425307Documentos Relacionados
- Plasma clearance of human extracellular-superoxide dismutase C in rabbits.
- Isolation and sequence of complementary DNA encoding human extracellular superoxide dismutase.
- Electrotransfection of human lymphoid and myeloid cell lines.
- Calcium-binding proteins in human carcinoma cell lines.
- Mutator phenotypes in human colorectal carcinoma cell lines.