Extrachromosomal Elements Cause a Reduced Division Potential in Nib 1 Strains of Saccharomyces Cerevisiae
AUTOR(ES)
Sweeney, R.
RESUMO
The nib 1 allele of yeast confers a sensitivity to an endogenous plasmid, 2μ DNA, in that nib 1 strains bearing 2μ DNA (cir(+)) exhibit a reduction in division potential. In the present study, the reduction in division potential characteristic of nib 1 cir(+) strains is shown to be dependent on the simultaneous presence of both the A and the D open reading frames of 2μ DNA as well as on the presence of an unidentified extrachromosomal element other than 2μ DNA. Furthermore, in nib 1 strains, an uncharacterized extrachromosomal element can cause a less severe reduction of division potential in the absence of intact 2μ DNA. Thus, the nib 1 allele may confer a generalized sensitivity to extrachromosomal elements.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1203751Documentos Relacionados
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